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Polygonum cuspidatum (Japanese Knotweed)

Rated 4.88 out of 5 based on 8 customer ratings
(8 customer reviews)

Polygonum cuspidatum (Japanese Knotweed) is clinically used as per Traditional Chinese Medicine (TCM) specifications based in its anti-inflammatory actions and ability to support the body’s endothelial cells against toxic damage.


Botanical Name: 

Polygonum cuspidatum

Common Name(s): 

  • Japanese Knotweed
  • Bushy Knotweed
  • Hu Zhang

Part Used: Root and Rhizome
Percentage of Alcohol Used: 40%
Herb to Menstruum Ratio: 1:4
Production Method: Whole-herb Percolation Extraction
NPN#: 80104332


  • Polygonum cuspidatum (Japanese Knotweed)
  • Gluten-Free Pharmaceutical-Grade Alcohol
  • Distilled Water


Remedy based on the theory of Traditional Chinese Medicine.


Adults 18 years and older - work up from 1 to 15 drops per day to a maximum of 15ml 4 times per day, or as directed by your health care provider.



  • If symptoms persist or worsen, or if new symptoms develop, discontinue use and consult a health care practitioner.
  • If you are taking prescription medications, consult a health care practitioner prior to use.
  • Mild side effects have been reported after oral administration of the herb or it's preparations including dry mouth, bitter taste, nausea, vomiting, abdominal pain, and diarrhea.
  • If you are pregnant or breastfeeding, do not use this product.

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*This product is not intended to diagnose, treat, cure, or prevent any disease. Please consult your health care provider for further information & dosing recommendations.

*This product is not intended to diagnose, treat, cure, or prevent any disease.
Please consult your health care provider for further information & dosing recommendations.

Additional Information About Polygonum cuspidatum (Japanese Knotweed)

Originally native to Japan, Taiwan, Korea, and parts of China, Japanese Knotweed (Polygonum cuspidatum) has become highly invasive worldwide. The root of this resilient plant is primarily utilized for its medicinal properties. Traditional Use With a history dating back 2000 years in China and Japan, Polygonum cuspidatum has only recently gained attention in the Western world. In Traditional Chinese Medicine (TCM), it has been traditionally used for clearing the blood, detoxification, and various internal and topical applications. Constituents Polygonum cuspidatum is laden with bioactive constituents, showcasing its remarkable therapeutic potential. At the forefront are the Stilbenes, with a special emphasis on Resveratrol, acknowledged for its robust cardiovascular benefits as a potent vasodilator and platelet aggregation inhibitor. Emodin, a neuroprotective compound, not only shields neurons but also inhibits multiple pathways such as JNK and MMP, contributing to its anti-inflammatory properties. Polydatin plays a crucial role in enhancing blood flow to vital organs. What sets Japanese Knotweed apart is the ability of these constituents, especially Resveratrol, to effectively cross the blood-brain barrier, ensuring direct and impactful interactions with the central nervous system. Synergistic Effects and Inhibitions Functioning as a synergist, Polygonum cuspidatum enhances antibiotic effectiveness. It also exhibits anti-inflammatory properties, particularly beneficial in reducing inflammation of endothelial cells associated with chronic exposure to Bartonella spp. pathogens. Remarkably, it is the only herb known to block all matrix metalloproteinase (MMP) pathways related to autoinflammation. Scientific Studies Backed by several hundred studies, Polygonum cuspidatum, particularly its Resveratrol content, is recognized as a potent vasodilator and platelet aggregation inhibitor. Emodin, another key compound, offers neuroprotective effects, pain reduction via P2X receptor activation in the brain, and inhibition of MMP. Human Studies Human studies focus on Polygonum cuspidatum's immunomodulatory effects in autoimmune cases, supporting immune function in both pathological lows and overstimulated states, such as autoimmunity. Ongoing research explores its potential in viral hepatitis, inflammation, and herpes infections. Additionally, there is significant interest in leveraging Polygonum cuspidatum to enhance the effects of pharmaceutical agents, particularly in neuroprotective studies related to Alzheimer's disease, Parkinson's disease, Huntington's disease, myasthenia gravis, multiple sclerosis, and traumatic brain injury. Cautions and Side Effects While generally safe, caution is advised when using Polygonum cuspidatum with blood-thinning herbs or medications, and it should be discontinued 10 days before surgery. Increased effects may be observed when used in conjunction with other medications. Contraindicated in pregnancy, potential side effects include minimal gastrointestinal upset, dry mouth, nausea, diarrhea, abdominal pain, and rarely, loss of taste.

Polygonum cuspidatum - Japanese Knotweed Polygonum cuspidatum - Japanese Knotweed


1. The Constituents of Medicinal Plants - An introduction to the chemistry and therapeutics of herbal medicine. 2nd edition. By Andrew Pengelly. 2. Herbal Antivirals - Natural Remedies for Emerging & Resistant Viral Infections. By Stephen Harrod Buhner 3. Natural Treatments For Lyme Coinfections - Anaplasma, Babesia, and Ehrlichia. By Stephen Harrod Buhner 4. Healing Lyme. Natural Healing of Lyme Borreliosis and the Coinfections Chlamydia and Spotted Fever Rickettsioses. By Stephen Harrod Buhner. 6. Advances for pharmacological activities of Polygonum cuspidatum - A review. Jia Ke et al. Pharm Biol. 2023 Dec;61(1):177-188. doi: 10.1080/13880209.2022.2158349. https://pubmed.ncbi.nlm.nih.gov/36620922 7. Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. Xiaoxv Dong et al. Phytother Res. 2016 Aug;30(8):1207-18. doi: 10.1002/ptr.5631. Epub 2016 May 18. https://pubmed.ncbi.nlm.nih.gov/27188216/ 8. Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway. Yan Lan et al. Drug Des Devel Ther. 2023 Oct 19:17:3151-3167. doi: 10.2147/DDDT.S420002. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37876500/ 9. Resveratrol and Its Effects on the Vascular System. Johannes M Breuss et al. Int J Mol Sci. 2019 Mar 27;20(7):1523. doi: 10.3390/ijms20071523. https://pubmed.ncbi.nlm.nih.gov/30934670/ 10. Health benefits of resveratrol administration. Sabina Galiniak et al. Acta Biochim Pol. 2019 Feb 28;66(1):13-21. doi: 10.18388/abp.2018_2749. https://pubmed.ncbi.nlm.nih.gov/30816367/ 11. Potential Adverse Effects of Resveratrol: A Literature Review. Abdullah Shaito et al. Int J Mol Sci. 2020 Mar 18;21(6):2084. doi: 10.3390/ijms21062084. https://pubmed.ncbi.nlm.nih.gov/32197410/

Customer reviews
Rated 4.88 out of 5
4.88 out of 5 stars
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8 reviews for Polygonum cuspidatum (Japanese Knotweed)

  1. A
    Amelia Verified Buyer 06/20/2022
    Rated 5 out of 5

    All of the Buhner herbs in one store!! Glad I found this company

  2. N
    Nikolaus Verified Buyer 08/24/2022
    Rated 5 out of 5

    Very pleased with purchase.

  3. D
    Dominic Verified Buyer 11/03/2021
    Rated 5 out of 5

    Great customer service and fast shipping.

  4. B
    Bernard Verified Buyer 02/09/2022
    Rated 5 out of 5

    my trusted source for tinctures.

  5. R
    René Verified Buyer 05/29/2022
    Rated 5 out of 5

    Fast shipping, great products

  6. A
    Andreap Verified Buyer 08/09/2022
    Rated 4 out of 5

    I just received my package from Apex Botanicals. Regular delivery was fast. I have not tried the product yet. The items matched the descriptions and was in good condition plus there was a gift inside my package, a tick remover was given to me.

  7. G
    Genevieve C Verified Buyer 03/26/2022
    Rated 5 out of 5

    Seems to do great for my symptoms

  8. F
    Filip Verified Buyer 10/24/2021
    Rated 5 out of 5

    really glad I can buy large volume on this site!

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Free Lyme Protocol Guide - Apex Botanicals


FREE Herbal Protocol Guide for Lyme &

This guide, written by our Lyme-literate experts, is designed to offer clarity amidst the confusion of endless treatment choices.

You'll gain insights into the nuanced physiological effects of the Lyme bacteria on various body systems and how herbs and supplements play a pivotal role in addressing these challenges.

By the end you'll have created your very own customized treatment protocol, tailored to your unique needs!


What makes Apex Botanical tinctures different from other herbal tinctures?

Our tinctures stand out due to the premium quality of herbs we use. Crafted at a concentration of 1:4, our herbal tinctures prioritize both potency and effectiveness.

Unlike many other companies that employ a uniform alcohol percentage across all products, our approach is nuanced. We tailor the alcohol concentration for each herb based on the distinct medicinal properties of the plant.

This strategy reflects our commitment to a sophisticated extraction of medicinal compounds, effectively setting Apex Botanicals apart in the realm of herbal tinctures.

How should I consume my herbal tincture?

Herbal tinctures are generally taken on an empty stomach (1 hour before and after meals). They can be taken directly or added to 1oz of water if the taste is hard to swallow.

Dosing of herbal tinctures will generally vary from 1 drop once per day up to 1 tsp 3 times per day. When taking anti-microbial herbal tinctures, starting at a lower dose and increasing slowly is the general rule of thumb.

*Be sure to speak with your primary care provider to determine the correct dose for your needs.

How long should I take my herbal tincture for?

The length of time a tincture should be taken will vary considerably based on your state of health, the infection / symptom you’re trying to treat and other medications or treatments you are concurrently taking.

Most people with chronic tick-borne infections take an herbal tincture for between 3 months and 2 years.

As a general rule, its recommended to take an herbal tincture for at least 1 month to see the best results.

Are herbal tinctures safe for children?

Generally speaking, it is safe for children to consume herbal tinctures, but dosing should be adjusted. Refrence 'Clarks Rule' for further information.

*Always consult your primary care provider before starting a new protocol or giving your child herbal tinctures.

Are herbal tinctures safe during pregnancy or while breastfeeding?

Some herbs are strictly contraindicated in pregnancy and should be avoided. We do our best to indicate this on the product information page but are not held liable for any errors or omissions.

If you are pregnant or breastfeeding consult your primary care provider before consuming any herbal tinctures.

Will my herbal tincture interact with medications or supplements?

Interactions of herbal tinctures with medications or supplements do exist. We strongly recommended consulting with your primary care provider or pharmacist before taking any herbal tinctures if you are concerned about potential contraindications.

What does a 1:4 ratio imply and how does it compare to 1:2 or 1:5+?

The ratio describes the concentration of a tincture. We use a 1:4 ratio, meaning 1 part dried herb (in grams) to 4 parts menstruum (the combined alcohol and herb).

A ratio of 1:5 has more liquid to the same amount of herb and is therefore more diluted.

A ratio of 1:10 or higher is very diluted and requires very high daily doses and is not recommended.

Tinctures made at 1:2 are often too concentrated for Lyme patients and commonly induce Herx reactions that can be very intense.

Most tinctures on the market are made at 1:5. We’ve chosen to use 1:4 to ensure greater potency while still being very safe and tolerable.

Does higher alcohol content mean an herbal tincture is more or less potent?

Using the correct alcohol percentage to extract the specific medicinal constituents of that herb is of highest importance when making a tincture. Using more or less alcohol essentially reflects the chemical nature of the compounds that we want to extract into the liquid portion.

A tincture made at 40% versus one made at 80% is not twice at strong. It simply implies that for the first herb, 40% alcohol will optimally extract the medicinal qualities. For the second herb, 80% is the concentration for optimal extraction.

We’ve gone to great lengths to ensure that our tinctures are made using the correct concentrations.

*Please note that not all herbal tinctures on the market are made with the appropriate alcohol concentration so use our site as a reference or conduct your own research to make sure you’re purchasing the best formulated tincture possible.

Click here to read our complete list of Frequently Asked Questions.