
Perilla frutescens (Perilla Seed)
Perilla frutescens is an annual herbal medicinal in the mint family that is native to East Asia. The seeds have traditionally been prescribed to treat depression-related diseases, anxiety, asthma, chest stuffiness, vomiting, coughs, colds, flus, allergies, fever, headache, stuffy nose, constipation, abdominal pain, and indigestion, and it has pain-killing and relaxing effects.
Perilla shows various biological activities such as antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotective effects. Most commonly, this herb is used for histamine management and MCAS.
Perilla frutescens is an annual herbal medicinal in the mint family that is native to East Asia. The seeds have traditionally been prescribed to treat depression-related diseases, anxiety, asthma, chest stuffiness, vomiting, coughs, colds, flus, allergies, fever, headache, stuffy nose, constipation, abdominal pain, and indigestion, and it has pain-killing and relaxing effects.
Perilla shows various biological activities such as antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotective effects. Most commonly, this herb is used for histamine management and MCAS.
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PRODUCT DETAILS
INGREDIENTS
CLINICAL USES
| Anti-allergic / Mast Cell Support | Traditionally used and studied for allergic conditions, with evidence suggesting it may help reduce histamine-related symptoms and support people with allergic rhinitis or other hypersensitivity patterns. |
| Anti-inflammatory | Contains compounds such as rosmarinic acid and other polyphenols that appear to help calm inflammatory signaling, making it one of its better-supported modern uses. |
| Antioxidant | Rich in antioxidant constituents that help reduce oxidative stress and protect tissues from free-radical damage. |
| Respiratory Support | Traditionally used for lung and airway complaints, and modern studies suggest potential benefit in allergic airway inflammation and asthma-type patterns. |
| Digestive Support | Traditionally regarded as a carminative/stomachic herb, used to help with nausea, digestive discomfort, and GI upset. |
| Immune Modulation | May help regulate overactive immune and inflammatory responses, especially where allergy-driven immune reactivity is part of the picture. |
| Mucosal / Barrier Support | Emerging evidence suggests perilla may help support epithelial barrier integrity, including skin and mucosal tissues, though this is a more secondary use than its allergy/inflammation role. |
RECOMMENDED DOSAGE
CAUTIONS & WARNINGS
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2 reviews for Perilla frutescens (Perilla Seed)
FAQ
What makes Apex Botanical tinctures different from other herbal tinctures?
Our tinctures stand out due to the premium quality of herbs we use. Crafted at a concentration of 1:4, our herbal tinctures prioritize both potency and effectiveness.
Unlike many other companies that employ a uniform alcohol percentage across all products, our approach is nuanced. We tailor the alcohol concentration for each herb based on the distinct medicinal properties of the plant.
This strategy reflects our commitment to a sophisticated extraction of medicinal compounds, effectively setting Apex Botanicals apart in the realm of herbal tinctures.
How should I consume my herbal tincture?
Herbal tinctures are generally taken on an empty stomach (1 hour before and after meals). They can be taken directly or added to 1oz of water if the taste is hard to swallow.
Dosing of herbal tinctures will generally vary from 1 drop once per day up to 1 tsp 3 times per day. When taking anti-microbial herbal tinctures, starting at a lower dose and increasing slowly is the general rule of thumb.
*Be sure to speak with your primary care provider to determine the correct dose for your needs.
How long should I take my herbal tincture for?
The length of time a tincture should be taken will vary considerably based on your state of health, the infection / symptom you’re trying to treat and other medications or treatments you are concurrently taking.
Most people with chronic tick-borne infections take an herbal tincture for between 3 months and 2 years.
As a general rule, its recommended to take an herbal tincture for at least 1 month to see the best results.
Are herbal tinctures safe for children?
Generally speaking, it is safe for children to consume herbal tinctures, but dosing should be adjusted. Refrence 'Clarks Rule' for further information.
*Always consult your primary care provider before starting a new protocol or giving your child herbal tinctures.
Are herbal tinctures safe during pregnancy or while breastfeeding?
Some herbs are strictly contraindicated in pregnancy and should be avoided. We do our best to indicate this on the product information page but are not held liable for any errors or omissions.
If you are pregnant or breastfeeding consult your primary care provider before consuming any herbal tinctures.
Will my herbal tincture interact with medications or supplements?
Interactions of herbal tinctures with medications or supplements do exist. We strongly recommended consulting with your primary care provider or pharmacist before taking any herbal tinctures if you are concerned about potential contraindications.
What does a 1:4 ratio imply and how does it compare to 1:2 or 1:5+?
The ratio describes the concentration of a tincture. We use a 1:4 ratio, meaning 1 part dried herb (in grams) to 4 parts menstruum (the combined alcohol and herb).
A ratio of 1:5 has more liquid to the same amount of herb and is therefore more diluted.
A ratio of 1:10 or higher is very diluted and requires very high daily doses and is not recommended.
Tinctures made at 1:2 are often too concentrated for Lyme patients and commonly induce Herx reactions that can be very intense.
Most tinctures on the market are made at 1:5. We’ve chosen to use 1:4 to ensure greater potency while still being very safe and tolerable.
Does higher alcohol content mean an herbal tincture is more or less potent?
Using the correct alcohol percentage to extract the specific medicinal constituents of that herb is of highest importance when making a tincture. Using more or less alcohol essentially reflects the chemical nature of the compounds that we want to extract into the liquid portion.
A tincture made at 40% versus one made at 80% is not twice at strong. It simply implies that for the first herb, 40% alcohol will optimally extract the medicinal qualities. For the second herb, 80% is the concentration for optimal extraction.
We’ve gone to great lengths to ensure that our tinctures are made using the correct concentrations.
*Please note that not all herbal tinctures on the market are made with the appropriate alcohol concentration so use our site as a reference or conduct your own research to make sure you’re purchasing the best formulated tincture possible.
Click here to read our complete list of Frequently Asked Questions.
SHARING THE GIFT OF WELLNESS
Free Herbal Protocol Guide for Lyme & Co-Infections
This comprehensive educational guide, developed by our Medical Director, Dr. Sal Meli ND, provides evidence-based insight into the physiological mechanisms of tick-borne infections and the supportive role of botanicals in addressing these challenges.
This resource is designed to simplify complex concepts and empower readers to make informed decisions about their approach to tick-borne infections.




I learn about Perilla through Neil Nathan’s book for my MCAS. this is one of the very few products I can tolerate so that is a very good sign